Nitrazepam has actually been affiliated with significant hepatic Conditions, just like other nitrobenzodiazepines. Nitrobenzodiazepines for instance nitrazepam, nimetazepam, flunitrazepam, and clonazepam tend to be more poisonous on the liver than other benzodiazepines as they are metabolically activated by CYP3A4 which can result in cytotoxicity.W